Cerebral Palsy

The research was led by Dr. Ari Melnick, assistant professor of developmental & molecular biology and medicine at Einstein, who also developed the new  lymphoma therapy. The study appears in the February 20 issue of the Proceedings of the National Academy of Sciences. Each year more than 60,000 Americans are diagnosed with B cell lymphomas—tumors [...]

Moreover, the researchers show, a treatment that blocks ceramide’s synthesis markedly improves insulin response and prevents the onset of diabetes in obese rodents. The findings therefore identify ceramide as a target for therapies aimed at improving insulin response and blood sugar control, the researchers said. "A collision of genetic and environmental factors has produced an [...]

There are two major strains of malaria effecting humans, P. vivax and P. falciparum. Although attention focuses on the more virulent P. falciparum, vivax malaria causes a huge amount of illness in the tropical countries of our region and puts many Australian travelers at risk of disease. Vivax malaria is becoming increasingly resistant to standard [...]

Even among higher organisms, shared genes are the rule rather than the exception, UC Berkeley and LBNL researchers say. Two new studies by University of California, Berkeley, scientists highlight the amazing promiscuity of genes, which appear to shuttle frequently between organisms, especially more primitive organisms, and often in packs. Such gene flow, dubbed horizontal gene [...]

The research team, led by Natalie Strynadka, a Howard Hughes Medical Institute (HHMI) international research scholar at the University of British Columbia in Vancouver, Canada, published its findings in the  journal Science. Penicillin and many newer antibiotics work by blocking a piece of the machinery bacteria use to construct their durable outer walls. Without these [...]

Drug delivery to the colon is an ongoing challenge to physicians. Many drugs are destroyed by stomach acids before they’ve had a chance to reach the intestine, where they usually are absorbed. Researchers have tried to circumvent this problem by inserting the drugs into carrier molecules that resist breakdown in the stomach but have had [...]

Several different classes of drugs are used to treat lipid disorders. Fibrates reduce the liver’s production of a triglyceride-carrying particle and speed up removal of triglycerides from the blood. Statins reduce cholesterol levels by inhibiting an enzyme that produces cholesterol in the liver. New, more potent and selective medications are being developed to treat lipid [...]

The new approach allows scientists to synthesize molecules without employing toxic catalysts, and it also does not generate alternate versions of drug molecules that can damage the body, two perennial issues that plague the manufacturing process. David MacMillan, one of the researchers on the team, said the discovery is important not only for its industrial [...]

In a study that appears in the April issue of the Journal of Clinical Investigation, Ignacio Anegon and colleagues from Centre Hopitalier Universitaire de Nantes, France, identified in rats treated with CD40Ig a population of regulatory immune cells that express CD8 and low levels of CD45RC. These cells were essential for the heart graft to [...]

Karl Scheidt, assistant professor of chemistry in the Weinberg College of Arts and Sciences at Northwestern University, and his research team have synthesized 10 different flavanones, a type of flavonoid, using a new general method they developed that takes advantage of one simple catalyst. The basic research gives chemists — for the first time — [...]